Why Genetic Testing Matters for Hair Loss

Hair loss is a deeply personal concern that affects millions worldwide. While traditional treatments often follow a one-size-fits-all approach, the reality is that not all hair loss is the same. Genetics, hormones, lifestyle, and nutrition all play critical roles in determining how hair responds to treatment. This is where Roots by GA revolutionizes the game: by leveraging genetic testing to create a truly personalized hair growth solution.

Understanding the Role of Genetics in Hair Loss

Hair loss, or alopecia, is often influenced by genetic factors that affect hormone regulation, follicle sensitivity, and nutrient metabolism. For instance, some people are more prone to male- or female-pattern baldness due to variations in the SRD5A1 and SRD5A2 genes, which control the conversion of testosterone into DHT, a hormone linked to follicle miniaturization and hair thinning.

Other genes, like SULT1A1, impact how the body responds to hair growth treatments such as minoxidil. Some individuals carry genetic variants that make standard doses less effective, highlighting the importance of personalized approaches rather than generic solutions.

Roots by GA recognizes that understanding these genetic differences is the key to achieving more predictable and effective results.

How the DNA Test Works

Roots by GA’s approach begins with a simple yet comprehensive cheek swab. Customers also complete a detailed lifestyle and medical questionnaire. This dual-input system allows the company to assess both genetic predispositions and environmental factors affecting hair growth.

The DNA test examines over 50 genes and key biomarkers associated with hair loss and treatment response. Using advanced pharmacogenetic analysis, Roots can predict how a person’s body is likely to react to various hair growth therapies. This includes responsiveness to topical treatments, DHT blockers, anti-inflammatory compounds, and essential nutrients.

Once the test is complete, the data is integrated into a personalized treatment plan. Roots then formulates a custom topical solution tailored to the individual, combining FDA-approved, prescription-grade, and clinically proven ingredients. Each formula can include up to 5–8 active compounds designed to target multiple pathways of hair loss.

Key Genes Roots by GA Tests and Why They Matter

Understanding which genes are analyzed helps explain why personalized treatment is more effective than generic products:

• SULT1A1 (Sulfotransferase 1A1) – Determines how well minoxidil is activated in the scalp.

• SRD5A1 & SRD5A2 (Steroid 5-Alpha-Reductase) – Influence DHT levels, guiding the use of DHT blockers like finasteride or dutasteride.

• MTHFR (Methylenetetrahydrofolate Reductase) – Impacts folate metabolism, which is critical for healthy cell and follicle growth.

• ACE (Angiotensin-Converting Enzyme) – Affects blood flow to the scalp, influencing the effectiveness of treatments like caffeine or minoxidil.

• GPR44-1 & GPR44-2 – Indicate sensitivity to prostaglandin D2, which can inhibit hair growth.

• PTGFR genes – Affect response to latanoprost, which promotes follicle health.

• COL1A1 (Collagen Type 1 Alpha 1) – Impacts collagen production for stronger hair.

• PTGES2, NQO1, BTD – Related to prostaglandin synthesis, oxidative stress defense, and biotin metabolism.

• CYP19A1 (Aromatase) – Influences hormone conversion affecting DHT levels.

• SLC23A1, GR-alpha, CRABP2, ZPR1, DMGDH, MUC1 – Genes tied to vitamin and mineral metabolism essential for hair strength.

By targeting these pathways, Roots by GA ensures each treatment plan addresses the unique causes of hair loss rather than relying on generic formulas.

Personalized Treatment vs. One-Size-Fits-All Solutions

Traditional hair loss solutions can be inconsistent because they don’t account for genetic variability. Roots by GAs personalized approach offers key benefits:

• Higher Effectiveness: Treatments match your genetic responsiveness.

• Safety: Reduces trial-and-error risks with prescription-grade formulations.

• Efficiency: Targets multiple pathways simultaneously.

• Convenience: One daily topical application.

• Support: Developed and approved under licensed dermatologists.

This strategic approach makes results more predictable and often quicker to appear.

What to Expect With a Personalized Genetic Hair Loss Plan

After sending in your DNA test, Roots creates a custom formula delivered to your door. Application is quick — a 30-second topical used once daily. Some users notice improvements within three months, but consistent use for six months typically yields the best results.

The system works for all stages of hair loss, using both genetics and lifestyle factors to create a targeted regrowth strategy.

Genetic testing is transforming how we approach hair loss. By understanding the factors that influence hair growth, companies like Roots by GA are creating safer, more effective, and personalized treatments. If traditional products haven’t worked for you or you want a DNA-informed approach, this offers a powerful and precise solution built for long-term success.